Key result
The C4B*Q0 allotype was significantly more prevalent in men aged 60-79 with acute myocardial infarction compared to healthy controls (OR 7.57), and carrier status was associated with higher mortality.
Why the study?
Is the C4B*Q0 allotype a risk factor for acute myocardial infarction in middle-aged individuals?
Case-Control (n=1,011)
Yes
Is the C4B*Q0 allotype a risk factor for acute myocardial infarction in middle-aged individuals?
Odds Ratio: 7.57 (95% CI 3.31–17.2)
Absolute Event Rate: 38% vs 8%
p-value: p=<0.0001
This study investigates whether the C4B*Q0 allotype is associated with acute myocardial infarction, potentially explaining its lower prevalence in the elderly population.
No takes yet. Share an insight, caveat, or question.
C4B*Q0 may flag elevated MI risk in middle-aged patients; extends genetic risk models for complement-mediated disease.
Krämer et al. (1994) conducted a case-control in Myocardial infarction (n=1,011). C4B*Q0 allotype vs. Non-carriers of C4B*Q0 allotype was evaluated on C4B*Q0 carrier status in age-matched men (60-79 years) (OR 7.57, 95% CI 3.31-17.2, p=<0.0001). The C4B*Q0 allotype was significantly more prevalent in men aged 60-79 with acute myocardial infarction compared to healthy controls (OR 7.57), and carrier status was associated with higher mortality.
Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context: