Catalytic Allylic Alkylation via the Cross-Dehydrogenative-Coupling Reaction between Allylic sp³C−H and Methylenic sp³C−H Bonds

A catalytic allylic alkylation was developed via the cross-dehydrogenative-coupling reaction of allylic sp3 C-H and methylenic sp3 C-H catalyzed by copper bromide and cobalt chloride in the presence of an oxidizing reagent, t-BuOOH. This methodology provides a direct way to use allylic sp3 C-H bonds for forming C-C bonds.