Reversibly Stabilized Multifunctional Dextran Nanoparticles Efficiently Deliver Doxorubicin into the Nuclei of Cancer Cells

Getting in there: Efficient intracellular delivery of anticancer drugs is achieved by using reversibly cross-linked dextran nanoparticles, which are rapidly destabilized under reductive environments that mimic those of the intracellular compartments. These nanoparticles show high drug loading efficiency and reduction-triggered release of doxorubicin in vitro as well as inside tumor cells, particularly to the cell nucleus (see scheme).