Key result
An intraoperative decision support system was associated with improved process measures, such as lower odds of tidal volume >10 ml/kg (28% vs 37%; OR 0.65, 95% CI 0.53-0.80), but not clinical outcomes.
Why the study?
Does a multiparameter intraoperative decision support system improve intraoperative processes of care and postoperative outcomes in adults under general anesthesia?
Cohort (n=26,769)
Does a multiparameter intraoperative decision support system improve intraoperative processes of care and postoperative outcomes in adults under general anesthesia?
Odds Ratio: 0.65 (95% CI 0.53–0.8)
Absolute Event Rate: 28% vs 37%
p-value: p=<0.001
An intraoperative decision support system improved process measures like tidal volume and crystalloid administration but did not significantly affect postoperative clinical outcomes.
May support selective intraoperative decision support adoption; leaves open causal outcome effects without randomized confirmation.
BACKGROUND: The authors hypothesized that a multiparameter intraoperative decision support system with real-time visualizations may improve processes of care and outcomes. METHODS: Electronic health record data were retrospectively compared over a 6-yr period across three groups: experimental cases, in which the decision support system was used for 75% or more of the case at sole discretion of the providers; parallel controls (system used 74% or less); and historical controls before system implementation. Inclusion criteria were adults under general anesthesia, advanced medical disease, case duration of 60 min or longer, and length of stay of two days or more. The process measures were avoidance of intraoperative hypotension, ventilator tidal volume greater than 10 ml/kg, and crystalloid administration (ml · kg · h). The secondary outcome measures were myocardial injury, acute kidney injury, mortality, length of hospital stay, and encounter charges. RESULTS: A total of 26,769 patients were evaluated: 7,954 experimental cases, 10,933 parallel controls, and 7,882 historical controls. Comparing experimental cases to parallel controls with propensity score adjustment, the data demonstrated the following medians, interquartile ranges, and effect sizes: hypotension 1 (0 to 5) versus 1 (0 to 5) min, P < 0.001, beta = -0.19; crystalloid administration 5.88 ml · kg · h (4.18 to 8.18) versus 6.17 (4.32 to 8.79), P < 0.001, beta = -0.03; tidal volume greater than 10 ml/kg 28% versus 37%, P < 0.001, adjusted odds ratio 0.65 (0.53 to 0.80); encounter charges $65,770 ($41,237 to $123,869) versus $69,373 ($42,101 to $132,817), P < 0.001, beta = -0.003. The secondary clinical outcome measures were not significantly affected. CONCLUSIONS: The use of an intraoperative decision support system was associated with improved process measures, but not postoperative clinical outcomes.
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Kheterpal et al. (2018) conducted a cohort in Adults under general anesthesia with advanced medical disease (n=26,769). Multiparameter intraoperative decision support system vs. Parallel controls (system used ≤74%) and historical controls was evaluated on Ventilator tidal volume greater than 10 ml/kg (adjusted OR 0.65, 95% CI 0.53 to 0.80, p=<0.001). An intraoperative decision support system was associated with improved process measures, such as lower odds of tidal volume >10 ml/kg (28% vs 37%; OR 0.65, 95% CI 0.53-0.80), but not clinical outcomes.
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