Key result
Telmisartan, but not amlodipine or moxonidine, ameliorated the impairment of endothelium-dependent relaxation and decreased oxidative stress markers in SHR-cp rats.
Why the study?
Does treatment with antihypertensive drugs (amlodipine, moxonidine, or telmisartan) improve endothelium-dependent relaxation in spontaneously hypertensive obese rats?
Population
SHR/NDmcr-cp rats
Design
Preclinical
Authors
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Telmisartan may improve endothelial function via oxidative stress reduction in obese hypertensive rats; leaves open human translation.
Does treatment with antihypertensive drugs (amlodipine, moxonidine, or telmisartan) improve endothelium-dependent relaxation in spontaneously hypertensive obese rats?
Telmisartan improves endothelial dysfunction in a rat model of metabolic syndrome by reducing oxidative stress and peroxynitrite formation, an effect not seen with amlodipine or moxonidine despite similar blood pressure lowering.
Kagota et al. (2007) studied Metabolic syndrome and hypertension. Telmisartan, amlodipine, and moxonidine vs. Untreated/each other was evaluated on Endothelium-dependent relaxation in response to acetylcholine and protein expression of endothelium NO synthase. Telmisartan, but not amlodipine or moxonidine, ameliorated the impairment of endothelium-dependent relaxation and decreased oxidative stress markers in SHR-cp rats.
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