Key result
Noninvasive imaging tracks survival, migration, and differentiation of implanted stem cells over time.
Noninvasive imaging modalities such as MRI, PET, SPECT, and bioluminescent imaging offer promising methods for tracking the survival and migration of stem cells implanted in infarcted myocardium.
Stem cell–based cellular cardiomyoplasty represents a promising therapy for myocardial infarction. Noninvasive imaging techniques would allow the evaluation of survival, migration, and differentiation status of implanted stem cells in the same subject over time. This review describes methods for cell visualization using several corresponding noninvasive imaging modalities, including magnetic resonance imaging, positron emission tomography, single-photon emission computed tomography, and bioluminescent imaging. Reporter-based cell visualization is compared with direct cell labeling for short- and long-term cell tracking.
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Zhou et al. (2006) conducted a review in Myocardial infarction. Noninvasive imaging techniques (MRI, PET, SPECT, bioluminescent imaging) was evaluated. Noninvasive imaging techniques, including MRI, PET, SPECT, and bioluminescent imaging, allow for the evaluation of survival, migration, and differentiation of implanted stem cells over time.
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