Key result
The combined carrier state for the ACE D and apoE epsilon 4 alleles was associated with a 16-fold increase in the odds of restenosis 6 months after coronary angioplasty (P<0.02).
Why the study?
Do ACE and apoE genotypes predict restenosis after percutaneous transluminal balloon coronary angioplasty in patients <70 years of age?
Population
207 subjects who underwent percutaneous transluminal balloon coronary angioplasty, and 136 population…
Comparison
Presence of angiotensin-converting enzyme… vs Absence of these specific genotypes (noncarriers)
Design
Cohort
Follow-up
6 months
Authors
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ACE I/D genotype shows no clear link to post-PTCA restenosis; leaves open potential apoE interactions for further study.
Cohort (n=207)
Do ACE and apoE genotypes predict restenosis after percutaneous transluminal balloon coronary angioplasty in patients <70 years of age?
Odds Ratio: 16
p-value: p=<0.02
The combined carrier state for the ACE D and apoE epsilon 4 alleles substantially increases the risk of angiographic restenosis after percutaneous transluminal balloon coronary angioplasty.
Bockxmeer et al. (1995) conducted a cohort in Restenosis after coronary angioplasty (n=207). ACE D and apoE epsilon 4 alleles vs. Non-carriers was evaluated on Restenosis (≥50% loss of gain at PTCA plus ≥50% luminal diameter stenosis) (OR 16, p=<0.02). The combined carrier state for the ACE D and apoE epsilon 4 alleles was associated with a 16-fold increase in the odds of restenosis 6 months after coronary angioplasty (P<0.02).
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