Key result
A third-generation quantitative cTnT point-of-care test showed 75% sensitivity and 100% specificity compared to the laboratory assay, missing levels between 0.03 and 0.10 ng/mL.
Why the study?
Does a third generation quantitative cardiac troponin T point-of-care test accurately detect elevated cTnT compared to a laboratory assay in patients with suspected acute coronary syndromes?
Population
133 unselected patients presenting to the hospital with possible cardiac chest pain, mean age 62 +/- 14…
Comparison
Third generation quantitative cardiac troponin T… vs Laboratory-based cardiac troponin T assay
Design
Cross-sectional
Authors
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POCT missed 25% of lab-positive troponin elevations; leaves open its reliability for ruling out injury pending prospective validation.
Cross-Sectional (n=133)
No
Does a third generation quantitative cardiac troponin T point-of-care test accurately detect elevated cTnT compared to a laboratory assay in patients with suspected acute coronary syndromes?
Effect estimate: kappa 0.831
Absolute Event Rate: 13.5% vs 18%
p-value: p=< 0.001
The third-generation cTnT point-of-care test has high specificity but insufficient sensitivity to detect low-level troponin elevations (0.03-0.10 ng/mL) compared to laboratory assays in patients with suspected acute coronary syndromes.
Hallani et al. (2005) conducted a cross-sectional in suspected acute coronary syndromes (n=133). Third generation quantitative cardiac troponin T (cTnT) point-of-care testing (POCT) vs. Laboratory assay (Roche Elecsys 2010 immunoassay analyser) was evaluated on Detection of serum cardiac troponin T ≥ 0.03 ng/mL (kappa 0.831, p=< 0.001). A third-generation quantitative cTnT point-of-care test showed 75% sensitivity and 100% specificity compared to the laboratory assay, missing levels between 0.03 and 0.10 ng/mL.
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