Key result
Long-term oral anticoagulant treatment was associated with significantly (2-fold) larger aortic valve calcifications compared to matched non-treated patients.
Why the study?
Does long-term oral anticoagulant treatment induce aortic valve calcification in patients with cardiovascular disease?
Observational
Does long-term oral anticoagulant treatment induce aortic valve calcification in patients with cardiovascular disease?
Effect estimate: 2-fold larger
Long-term use of vitamin K antagonist oral anticoagulants is associated with a 2-fold increase in aortic valve calcification, highlighting a potential adverse effect of this antithrombotic therapy.
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May warrant caution with long-term OACs; leaves open causal role in human calcification pending prospective data.
Schurgers et al. (2004) conducted an observational in Cardiovascular disease. Oral anticoagulants (OACs) vs. No OAC treatment was evaluated on Grade of aortic valve calcification (2-fold larger). Long-term oral anticoagulant treatment was associated with significantly (2-fold) larger aortic valve calcifications compared to matched non-treated patients.