Key result
Maximal negative dP/dt correlated highly with the end of aortic flow (r=0.982, mean error <0.4 ms) in anesthetized dogs, suggesting its utility for determining systolic time.
Why the study?
Does maximal negative dP/dt accurately indicate the end of systole compared to the end of aortic flow in anesthetized dogs?
Does maximal negative dP/dt accurately indicate the end of systole compared to the end of aortic flow in anesthetized dogs?
Answers are grounded in this paper and cite their sources.
Maximal negative dP/dt is a highly accurate indicator of the end of ventricular ejection, which is useful when only ventricular pressure is available.
The maximal negative peak of the first derivative of left ventricular pressure was examined as an index of the end of ventricular ejection by comparing it with the end of aortic flow. Under varying heart rate and afterload situations in anesthetized dogs, a correlation coefficient of 0.982 was obtained with a mean error of less than 0.4 ms. This may be a useful end point for determining systolic time where only ventricular pressure is available.
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Francis L. Abel (1981) studied this question. Maximal negative dP/dt vs. End of aortic flow was evaluated on Correlation with the end of aortic flow (r=0.982). Maximal negative dP/dt correlated highly with the end of aortic flow (r=0.982, mean error <0.4 ms) in anesthetized dogs, suggesting its utility for determining systolic time.
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