Key result
Five monoclonal antibodies were used to map evolutionarily conserved epitopes specific for fast myosin heavy chain isoforms to the globular head and helical tail fragments near the ATPase active site.
Population
Chicken skeletal muscle myosin heavy chain isoforms, as well as MHCs from rat, amphioxus, nematode…
Design
Preclinical
Authors
Loading...
These mAbs enable isoform-specific MHC mapping in muscle; leaves open extension to cardiac or human disease models.
The study maps specific epitopes of fast myosin heavy chain isoforms to regions near the ATPase active site and demonstrates their conservation across vertebrate evolution.
Miller et al. (1989) studied this question. cDNA expression strategy and monoclonal antibodies was evaluated on Localization of amino acid sequences specific for fast myosin heavy chain isoforms. Five monoclonal antibodies were used to map evolutionarily conserved epitopes specific for fast myosin heavy chain isoforms to the globular head and helical tail fragments near the ATPase active site.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: