Key result
The proximity of myosin heads to actin filaments modulates skeletal muscle calcium sensitivity in response to length, pH, regulatory light-chain phosphorylation, and temperature.
The proximity of myosin heads to actin filaments is a key mechanism modulating calcium sensitivity in skeletal muscle.
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Myofilament lattice spacing modulates Ca2+ sensitivity via myosin-actin proximity in skeletal muscle; leaves open translation to cardiac myofilament regulation.
A common mechanism affecting Ca(2+) sensitivity in skeletal muscle is the proximity of myosin heads with actin filaments, a function of myofilament lattice spacing and myosin head mobility with respect to the myosin filament. This is an important mechanism of pCa(2+)(50) modulation by length, pH, regulatory light-chain phosphorylation, and temperature.
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Brian R. MacIntosh (2003) studied this question. The proximity of myosin heads to actin filaments modulates skeletal muscle calcium sensitivity in response to length, pH, regulatory light-chain phosphorylation, and temperature.
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