Key result
Electrical stimulation increased cGMP formation by approximately 166% in fast-twitch skeletal muscle from control mice, an effect requiring both nNOS and eNOS.
Population
Isolated fast-twitch extensor digitorum longus muscles, slow-twitch soleus muscles, and cremaster muscles…
Comparison
Electrical stimulation, NOS inhibitor… vs Noncontracting muscles, or muscles from control…
Design
Preclinical
Authors
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Indicates nNOS-derived NO elevates cGMP in stimulated fast-twitch muscle; leaves open its role in human microvascular regulation.
Both nNOS and eNOS are required for contraction-induced increases in cGMP and NO-dependent vascular relaxation in fast-twitch skeletal muscle.
Lau et al. (2000) studied this question. Electrical stimulation vs. Noncontracting muscles / knockout mice was evaluated on cGMP formation. Electrical stimulation increased cGMP formation by approximately 166% in fast-twitch skeletal muscle from control mice, an effect requiring both nNOS and eNOS.
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