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High Resolution Image Download MS PowerPoint Slide Due to overexpression of hydrogen sulfide (H 2 S) in colorectal tumors, the combination of H 2 S targeting with traditional phototherapy is expected to achieve precision treatment of colorectal tumors and reduce side effects while enhancing therapeutic efficacy. In this study, we developed a theranostic nanoplatform ( N-BOD-P-T ) of H 2 S-activated dual-modal phototherapy for precise photoablation of colorectal tumors utilizing photodynamic therapy (PDT) and photothermal therapy (PTT) guided by H 2 S-activated NIR-II imaging. N-BOD-P-T could selectively accumulate at H 2 S-overexpressed colorectal tumors with a fluorescence conversion from NIR-I to NIR-II. Subsequent dual-modal phototherapy would exert synergistic effects through the following mechanisms: 1. PDT-generated reactive oxygen species could inhibit the expression of heat shock proteins to reduce tumor thermotolerance caused by PTT; 2. PTT enhanced tumor blood flow and oxygen supply, thereby addressing oxygen consumption in PDT. Collectively, this H 2 S-activated NIR-II dual-modal phototherapy nanoplatform represents a promising theranostic tool for the precision treatment of colorectal cancer.
Wu et al. (Wed,) studied this question.