Key result
Preoperative inflammatory biomarkers including neutrophil-to-lymphocyte ratio, systemic immune-inflammatory index, and platelet-lymphocyte ratio demonstrated poor predictive ability for 1-year mortality (AUCs 0.598, 0.549, and 0.569, respectively).
Why the study?
This study aimed to investigate whether biomarkers measured using complete blood count can predict mortality in geriatric patients undergoing proximal femoral nail fixation for intertrochanteric femur fractures.
Do inflammatory markers predict 1-year mortality in geriatric patients undergoing proximal femoral nail fixation for intertrochanteric femur fractures?
Observational (n=247)
No
Do inflammatory markers predict 1-year mortality in geriatric patients undergoing proximal femoral nail fixation for intertrochanteric femur fractures?
Inflammatory markers and surgical timing are associated with 1-year mortality in geriatric patients undergoing proximal femoral nailing for osteoporotic fractures.
Inflammatory markers may aid mortality risk stratification in geriatric femur fracture patients; leaves open need for prospective validation before clinical use.
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Danışman et al. (2023) conducted an observational in Osteoporotic intertrochanteric femur fracture (n=247). Inflammatory biomarkers (NLR, PLR, SII) vs. Low vs high biomarker levels was evaluated on 1-year mortality predictability (Area Under the Curve) (AUC 0.598 for NLR, p=0.009). Preoperative inflammatory biomarkers including neutrophil-to-lymphocyte ratio, systemic immune-inflammatory index, and platelet-lymphocyte ratio demonstrated poor predictive ability for 1-year mortality (AUCs 0.598, 0.549, and 0.569, respectively).
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