Key result
Elevated visfatin expression is linked to ruptured coronary plaques and leukocyte activation in male STEMI.
Observational
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We demonstrated that visfatin expressed in monocytes and neutrophils and increased their reactivity in male acute ST-segment elevation myocardial infarction patients. Furthermore, visfatin was strongly appeared in lipid rich coronary rupture plaques and macrophages. These results suggest another explanation about leukocytes mediated visfatin that may play a pathogenesis role in coronary vulnerable plaques rupture.
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Chiu et al. (2012) conducted an observational in Acute ST-segment elevation myocardial infarction. Visfatin expression was evaluated on Visfatin expression and reactivity in monocytes and neutrophils. Visfatin expression was increased in monocytes and neutrophils in male STEMI patients and was strongly present in lipid-rich coronary rupture plaques and macrophages.
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