Key result
Targeted superparamagnetic nanoparticles detect atherosclerotic cholesterol crystals on MRI.
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Water-soluble, β-cyclodextrin conjugated superparamagnetic nanoparticles have been constructed. These particles showed selective binding to cholesterol crystals, which opens the door for the detection of cholesterol crystal-related diseases such as atherosclerosis by magnetic resonance imaging (MRI).
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Li et al. (2012) studied this question. β-cyclodextrin conjugated superparamagnetic nanoparticles selectively bound to cholesterol crystals, demonstrating potential for detecting atherosclerosis via magnetic resonance imaging.
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