What question did this study set out to answer?

This research investigates how human neutrophil elastase affects platelet function and structure during coagulation.

February 1, 1985Journal of Clinical InvestigationOpen Access

Human neutrophil elastase modulates platelet function by limited proteolysis of membrane glycoproteins.

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Authors

MBMark S. BrowerCornell University RLRichard I. LevinArnold P Gold Foundation KGKimberly GarryNewYork–Presbyterian Hospital

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Implication

Randomized trial shows that human neutrophil elastase inhibits thrombin-induced platelet function, suggesting a significant impact on coagulation processes.

Key Points

This research investigates how human neutrophil elastase affects platelet function and structure during coagulation.
Analyzed the effect of human neutrophil elastase on platelet aggregation and glycoprotein levels
Measured thrombin binding sites and conducted proteolysis studies on glycoproteins
Utilized sodium dodecyl sulfate-polyacrylamide gel electrophoresis and immunoprecipitation techniques
Elastase significantly inhibited thrombin-induced platelet aggregation and reduced thrombin binding sites from 31 to 12 per platelet (P<0.05)
Identified proteolytic cleavage of glycoprotein Ib in elastase-treated platelets
Found a new glycoprotein in the supernatant of elastase-treated platelets not present in untreated samples

Cite This Study

Brower et al. (1985) studied this question.

synapsesocial.com/papers/6a650940dfe9f9fc9bef3fd8 https://doi.org/10.1172/jci111744

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Implication

Randomized trial shows that human neutrophil elastase inhibits thrombin-induced platelet function, suggesting a significant impact on coagulation processes.

Human neutrophil elastase modulates platelet function by limited proteolysis of membrane glycoproteins.

Discussion

Member takes

Implication

Key Points

Cite This Study

Human neutrophil elastase modulates platelet function by limited proteolysis of membrane glycoproteins.

Discussion

Member takes

Implication

Key Points

Cite This Study

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