Synthesis and in vitro activity of new semisynthetic coumermycin analogs: Chemical modification at the C-3 amide.

Several new semi-synthetic coumermycin analogs, which carry a polar substituent at the C-3 amide moiety have been prepared. In vitro antibacterial activity of these new analogs against Gram-positive organisms, particularly methicillin-resistant strains of Staphylococci species has been described.