Key result
2,3-Butanedione monoxime produced a rapid, dose-dependent, and reversible abolition of gap junctional communication in rat cardiac myocytes.
Population
Rat cardiac myocytes
Design
Preclinical
Authors
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BDM enables acute reversible gap junction blockade in isolated myocytes; leaves open translation to intact hearts or clinical models.
BDM causes rapid, dose-dependent, and reversible blockade of gap junctional communication in rat cardiac myocytes.
Verrecchia et al. (1997) studied this question. 2,3-Butanedione monoxime (BDM) was evaluated on Gap junctional communication (cytosolic continuity between cells). 2,3-Butanedione monoxime produced a rapid, dose-dependent, and reversible abolition of gap junctional communication in rat cardiac myocytes.
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