Prevalence of the Different Causes of Troponin Elevation in a Multicenter Registry in Bariloche. Link Between the Magnitude of Troponin Elevation and its Etiology

Objectives: To determine the prevalence of acute myocardial infarction (AMI) and other etiologies in patients with elevated troponin, to associate troponin values with the etiology, and to define the optimal cut-off point to differentiate AMI from other causes.Methods: All patients with elevated troponin who were hospitalized within 1 year and registered in the REGIBAR study were included.Magnitude was analyzed with the highest dose value/baseline value.The ROC curve and the Youden index were used to determine the optimal cut-off point.Results: A total of 150 cases were included (age: 66.3 13.8 years, 71% male); 109 AMI (age: 71.1 years, 63.5% male), 18 (12%) with other cardiac causes, 15 (10%) with non-cardiac causes, and 8 (5.3%) with no evident etiology.The optimal cut-off point for troponin dose/baseline value to discriminate AMI was > 3.15.Conclusions: A 73% of inpatients with elevated troponin were AMI cases (> 3.15 times the cut-off point).Heart failure was the second most common cause of elevated troponin.