Successful desensitization to gonadotropin‐releasing hormone analogue triptorelin acetate using a sustained‐release depot preparation

Gonadotropin-releasing hormone (GnRH) analogues are commonly used in pediatric patients in the treatment of central precocious puberty1 . GnRH analogues suppress the secretion of gonadotropins and sex hormones, preventing progression to advanced puberty and reduced final adult height secondary to accelerated fusion of growth plates. GnRH analogues are also used in adults for treatment of endometriosis2 and prostatic cancer3 . Hypersensitivity reactions to GnRH analogues are exceedingly rare4-6 and to date, we are unaware of any desensitization protocols for GnRH hypersensitivity in the literature or used in clinical practice. This article is protected by copyright. All rights reserved.