Template‐Assembled Synthetic Proteins (TASP). Cyclic Templates with Incorporated Turn‐Inducing Mimics

The 8‐amino‐5,6,7,8‐tetrahydronaphth‐2‐oic acid ( 1 ), 8‐(aminomethyl)‐5,6,7,8‐tetrahydronaphth‐2‐oic acid ( 2 ), and 8‐(aminomethyl)naphth‐2‐oic acid ( 3 ) were synthesized in their protected forms as turn‐inducing dipeptide mimics. Two of them ( 2 and 3 ) were incorporated into a novel type of cyclic, peptide‐based structures (see 21 and 34 – 36 ) designed as templates for the synthesis of TASP molecules.