Population
Normal and hypertrophied adult rat ventricular cardiomyocytes
Comparison
In vivo delivery of Cy3-tagged siRNAs for… vs Control isolated cardiomyocytes
Design
Preclinical
Key result
Specific knockdown established Orai3, but not Orai1, as the critical partner of STIM1 carrying voltage-independent Ca(2+) entries in adult hypertrophied rat cardiomyocytes.
Authors
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No immediate clinical implications; leaves open Orai3 as a research target in hypertrophy models.
Orai3 is identified as the essential partner of STIM1 driving voltage-independent calcium entry and arachidonic acid-activated currents in adult cardiomyocytes during hypertrophy.
Saliba et al. (2014) studied Cardiac hypertrophy. Orai1 and Orai3 knockdown via siRNA vs. Control isolated cardiomyocytes was evaluated on Voltage-independent Ca(2+) entries and Orai-mediated currents. Specific knockdown established Orai3, but not Orai1, as the critical partner of STIM1 carrying voltage-independent Ca(2+) entries in adult hypertrophied rat cardiomyocytes.