Key result
Purified IgG from patients with lupus anticoagulant significantly lowered the rate of activation of purified protein C by HUVEC in the presence of thrombin (43% inhibition).
Effect estimate: 43% inhibition
IgG from patients with lupus anticoagulant inhibits thrombomodulin-dependent protein C activation on endothelial cells, providing a potential mechanism for their prothrombotic state.
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Patient IgG does not alter endothelial PGI2 or t-PA/PAI release in vitro; leaves open alternative thrombotic mechanisms in lupus anticoagulant.
Cariou et al. (1988) studied Lupus anticoagulant (n=16). Purified immunoglobulin G (IgG) from patients with lupus anticoagulant was evaluated on Rate of activation of purified protein C (PC) by HUVEC in the presence of thrombin (43% inhibition). Purified IgG from patients with lupus anticoagulant significantly lowered the rate of activation of purified protein C by HUVEC in the presence of thrombin (43% inhibition).
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