Key result
The diurnal pattern of 24-h leptin levels was present in healthy controls and noncachexic COPD patients (P<0.0001) but was strikingly absent in cachexic COPD patients.
Why the study?
Does the circadian rhythm of circulating leptin correlate with autonomic nervous system function (measured by HRV) in cachexic patients with COPD?
Observational (n=24)
Does the circadian rhythm of circulating leptin correlate with autonomic nervous system function (measured by HRV) in cachexic patients with COPD?
The loss of circadian rhythm of circulating leptin correlates with altered very low frequency heart rate variability in cachexic COPD patients, suggesting a link to neuroendocrine and thermoregulatory abnormalities.
Loss of leptin circadian rhythm may link to autonomic dysfunction in cachexic COPD; leaves open causal role and therapeutic targeting.
Cachexic patients with chronic obstructive pulmonary disease (COPD) show abnormalities of the autonomic nervous system (ANS), neuroendocrine function, and energy expenditure. Leptin has been implicated in the regulation of ANS, neuroendocine function, and thermogenesis in humans. We assessed the physiologic significance of the circadian rhythm of circulating leptin using power spectrum analysis of heart rate variability (HRV) in nine cachexic male patients with COPD, eight noncachexic patients with COPD, and seven healthy control subjects. A diurnal pattern of 24-h leptin levels was present in both the control subjects (analysis of variance [ANOVA]; F = 7.80, p < 0.0001) and noncachexic COPD patients (F = 9.29, p < 0.0001), but was strikingly absent in the cachexic COPD patients (F = 2.09, p = NS). Analysis of HRV demonstrated that the diurnal rhythm of 24-h very low frequency (VLF; 0.003 to 0.04 Hz) showed significantly identical fluctuations with those of 24-h leptin levels, in all of the three groups (r = 0.388, p < 0.0001). Because VLF has been considered to reflect neuroendocrine and thermoregulatory influences, these data may suggest that the loss of circadian rhythm of circulating leptin has clinical importance in the pathophysiologic features in cachexic patients with COPD.
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Takabatake et al. (2001) conducted an observational in Chronic Obstructive Pulmonary Disease (COPD) (n=24). Cachexia vs. Noncachexic COPD patients and healthy controls was evaluated on Diurnal pattern of 24-h leptin levels (p=<0.0001). The diurnal pattern of 24-h leptin levels was present in healthy controls and noncachexic COPD patients (P<0.0001) but was strikingly absent in cachexic COPD patients.
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