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May 20, 2026The Cell SurfaceOpen Access

Acetylation and accessibility of Cryptococcus neoformans cell wall chitosans influence the strength of host immune responses

Margareta J. Hellmann Rajendra Upadhya Evelyn Tchoub Bruno M. Moerschbacher Jennifer K. Lodge Stefan Cord-Landwehr

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Abstract

-related disease caused by insufficient and excessive immune responses, and may accelerate the development of effective cell-based vaccines.

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Cite This Study

Hellmann et al. (2026) studied this question.

synapsesocial.com/papers/6a6549ea5d9cef6387b2e337 https://doi.org/10.1016/j.tcsw.2026.100175

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Polymorphic α‐Glucans as Structural Scaffolds in <i>Cryptococcus</i> Cell Walls for Chitin, Capsule, and Melanin: Insights From <sup>13</sup> C and <sup>1</sup> H Solid‐State NMROriginal Research · 2025 · 19 citations
2Chitosan, the Deacetylated Form of Chitin, Is Necessary for Cell Wall Integrity in <i>Cryptococcus neoformans</i>Original Research · 2007 · 379 citations
3Chitinases Are Essential for Sexual Development but Not Vegetative Growth in <i>Cryptococcus neoformans</i>Original Research · 2009 · 39 citations
4Cell Wall Chitosan Is Necessary for Virulence in the Opportunistic Pathogen Cryptococcus neoformansOriginal Research · 2011 · 126 citations
5A Chitin Synthase and Its Regulator Protein Are Critical for Chitosan Production and Growth of the Fungal Pathogen <i>Cryptococcus neoformans</i>Original Research · 2005 · 245 citations

Identification and Cloning of a Cryptococcal Deacetylase That Produces Protective Immune Responses2002
Characterization of Two Novel Cryptococcal Mannoproteins Recognized by Immune Sera2005
<i>Cryptococcus neoformans</i>Strains and Infection in Apparently Immunocompetent Patients, China2008
Resolving aromatic spectral congestion in whole-cell solid-state NMR: Signatures of condensed tannins and lignin in plant tissuesThe Cell Surface · 2026
Mass distribution profiling of cell wall matrix polysaccharide biosynthesis mutants reveals alterations in non-targeted matrix polysaccharidesThe Cell Surface · 2026

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