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Through the energy transfer process, mild transformations can be achieved that are often difficult to realize under thermodynamic conditions. Herein, a visible-light-driven deoxygenative coupling of 1,2-dicarbonyl compounds for C–O, C–S, and C–N bonds construction is developed via triplet state 1,2-dicarbonyls, affording a wide range of α-functionalized ketones/esters under transition-metal and external photocatalyst free conditions. The usefulness of this method is demonstrated by gram-scale synthesis, late-stage functionalization of various carboxylic acid drugs, and the synthesis of natural products and drug molecules. Visible-light photochemistry, which includes energy transfer processes, can enable transformations that are difficult or prohibited from thermal pathways. Here, the authors develop a deoxygenative coupling of 1,2-dicarbonyl compounds with a variety of nucleophiles via energy transfer.
Luo et al. (Fri,) studied this question.