Key result
Crack cocaine use is linked to internal carotid vasospasm and secondary thrombosis causing ischemic stroke.
Case Report (n=3)
No
BACKGROUND: "Crack" cocaine (alkaloidal cocaine) induces ischemic stroke. However, the mechanisms by which this occurs are not well documented in humans. We present pertinent information on three patients whose ischemic strokes involved the territory of the internal carotid artery and were associated with crack use. CASE DESCRIPTIONS: These patients were investigated clinically, radiologically, intraoperatively, and/or histopathologically at the same institution, and the diagnostic evaluations did not reveal a definite cardiac or hematologic cause of stroke. Large filling defects were noted on conventional carotid angiography in two of these patients; in the third patient, the histopathological changes were compatible with vasospasm. To our knowledge, these changes have not been previously documented in human arteries. CONCLUSIONS: We suggest that some brain infarcts among crack cocaine users may result from vasospasm of large arteries and secondary intravascular thrombosis.
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Konzen et al. (1995) conducted a case report in Ischemic stroke (n=3). Crack cocaine (alkaloidal cocaine) was evaluated on Radiological and histopathological mechanisms of stroke. Crack cocaine use was associated with large artery vasospasm and secondary intravascular thrombosis in three patients with ischemic strokes in the internal carotid artery territory.
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