April 6, 2000New England Journal of Medicine409 citations
View Full PaperCoronary Heart Disease in Patients with Diabetes
Key Result
Type 2 diabetes increases the risk of coronary heart disease by a factor of two to four, with a greater relative increase observed in women than in men.
Structured PICO
What is the risk of coronary heart disease in patients with type 2 diabetes?
P
Population
Patients with type 2 diabetes
O
Outcome
Coronary heart disease incidencehard clinical
Type 2 diabetes significantly increases the risk of coronary heart disease, particularly eliminating the typical cardioprotective effect seen in women.
Main Result
Effect estimate: RR 2 to 4
Abstract
Type 2 diabetes increases the risk of coronary heart disease by a factor of two to four.1 The relative increase in the rate of coronary heart disease among patients with diabetes in most studies is greater for women than for men. In the Framingham Heart Study1 (but not in all studies), the absolute incidence of coronary heart disease is similar among both men and women with diabetes, leading to the frequently made assertion that diabetes may eliminate women's protection against coronary heart disease. The increase in the incidence of coronary events is greater for more severe clinical outcomes, such as . . .