Mitochondrial ATPase 6,8 Associated with Brain Tumours in Patients Compared to Adjacent Normal Brain Cells

A ccording to WHO, a primary brain tumour includes 160 types. The most common of these categories are gliomas and medulloblastoma. Gliomas are known by histological standards as consisting of the presence of mitoses, cytoplasmic morphology or devious nuclear, glomeruloid angiogenesis and necrosis. Based on the WHO classification system, gliomas can be categorized into four different grades with increasing malignancy apportion (Rich and Eyler, 2008). Grade 4 (malignant glioblastoma multiform-GBM) is considered to have the highest invasiveness amongst all the grades. GBM can cause different symptoms-for instance, necrosis, excessive vascular proliferation, and rising expression angiogenic factors (Brat et al., 2015, Friedman et al., 2009). The annual prevalence of malignant glioblastoma is about 5 cases per 100,000 people in the world. Also, more than 18,000 new cases are known in the United States each year (Liu et al., 2010, Wen and Kesari, 2008). Treatments of malignant glioblastoma include surgical resection and radiation therapy, with some new studies in chemotherapy drugs, such as Temozolomide, Bevacizumab, Irinotecan, etc. Based on recent studies, simultaneous use of these drugs with other treatments is more effective when compared with radiation therapy alone (Stupp et al., 2005, Vredenburgh et al., 2007). There are many studies about the relevance of the connection between mtDNA and well-known diseases like cancers and diabetes. So, mitochondrial genes could participate in cancers-for example, breast, colon and kidney cancers (Raule et al., 2007).