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USP22 suppresses the NLRP3 inflammasome by degrading NLRP3 via ATG5-dependent autophagy | Synapse

July 28, 2022Autophagy75 citationsOpen Access

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USP22 suppresses the NLRP3 inflammasome by degrading NLRP3 via ATG5-dependent autophagy

QDQianqian DiInstitute of Infection and Immunity XZXibao ZhaoShenzhen University HTHaimei TangZhejiang University

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Abstract

ATG5: autophagy related 5; ATP: adenosine triphosphate; CASP1: caspase 1; IL18: interleukin 18; IL1B/IL-1β: interleukin 1 beta; LPS: lipopolysaccharide; NLRC4: NLR family, CARD domain containing 4; NLRP3: NLR family, pyrin domain containing 3; PYCARD/ASC: PYD and CARD domain containing; TNF/TNF-α: tumor necrosis factor; USP22: ubiquitin specific peptidase 22.

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Cite This Study

Di et al. (Thu,) studied this question.

synapsesocial.com/papers/6a6571a6a4a227fa25f71d9c https://doi.org/https://doi.org/10.1080/15548627.2022.2107314