Key result
Elevated levels of soluble interleukin-2 receptors were detected in the serum and cerebrospinal fluid of patients with acute and subacute encephalitis, suggesting local T-lymphocyte activation.
Observational
Soluble IL-2 receptors in the cerebrospinal fluid may serve as a specific marker for cerebral T-lymphocyte activation in certain neurological diseases.
May indicate intrathecal immune activation in encephalitis; hypothesis-generating for CSF sIL-2R as biomarker.
Elevated levels of soluble interleukin-2 receptors were present in the serum from patients with acute primary and postinfectious encephalitis and subacute sclerosing panencephalitis. In addition, soluble interleukin-2 receptors were detected in the cerebrospinal fluid from patients with acute primary encephalitis. Their presence in the cerebrospinal fluid was not explained by damage to the blood-brain barrier and our data attest to their local origin. This suggests that it may be possible in certain neurological diseases to detect cerebral T-lymphocyte activation through a specific marker in the cerebrospinal fluid.
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Boutin et al. (1987) conducted an observational in Acute and subacute encephalitis. Soluble interleukin-2 receptors was evaluated on Presence of soluble interleukin-2 receptors in serum and cerebrospinal fluid. Elevated levels of soluble interleukin-2 receptors were detected in the serum and cerebrospinal fluid of patients with acute and subacute encephalitis, suggesting local T-lymphocyte activation.
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