Key result
Pactamycin differentially reduced the synthesis of poliovirus proteins in infected HeLa cells, indicating their relative distance from the initiation site and suggesting a specific gene order.
Pactamycin's differential inhibition of poliovirus protein synthesis provides a method for genetic mapping of the viral genome.
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Pactamycin alters poliovirus protein ratios in infected cells; leaves open whether the genome uses multiple initiation sites.
Taber et al. (1971) studied Poliovirus infection. Pactamycin was evaluated on Spectrum of poliovirus proteins synthesized. Pactamycin differentially reduced the synthesis of poliovirus proteins in infected HeLa cells, indicating their relative distance from the initiation site and suggesting a specific gene order.
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