Key result
Neuraxial anesthesia was associated with lower 30-day mortality (3.8% vs 9.7%) compared to general anesthesia, with general anesthesia independently associated with increased mortality risk (adjusted OR 2.62) in elderly hip fracture patients.
Why the study?
Hip fractures in elderly patients carry high morbidity and mortality, and anesthetic technique may influence perioperative stability, complications, pain, and recovery.
Does neuraxial anesthesia reduce postoperative complications and 30-day mortality in elderly patients undergoing hip fracture surgery compared to general anesthesia?
Observational (n=300)
No
Does neuraxial anesthesia reduce postoperative complications and 30-day mortality in elderly patients undergoing hip fracture surgery compared to general anesthesia?
Odds Ratio: 2.62 (95% CI 1.01–6.78)
Absolute Event Rate: 3.8% vs 9.7%
p-value: p=0.047
In elderly patients undergoing hip fracture surgery, neuraxial anesthesia is associated with significantly lower 30-day mortality and fewer postoperative complications than general anesthesia.
Neuraxial anesthesia was associated with fewer complications and lower mortality; leaves open preference over general anesthesia pending randomized confirmation.
Background: Hip fractures in elderly patients are associated with high postoperative morbidity, prolonged hospitalization, functional decline, and early mortality. The anesthetic technique used during surgery may influence perioperative stability, postoperative complications, pain control, and recovery outcomes. Objective: To compare postoperative outcomes between neuraxial anesthesia and general anesthesia in elderly patients undergoing hip fracture surgery and to identify predictors of postoperative complications and 30-day mortality. Methods: This comparative observational study included 300 patients aged 65 years and above undergoing hip fracture surgery. Patients were categorized according to anesthetic technique into neuraxial anesthesia (n=156) and general anesthesia (n=144) groups. Baseline characteristics, intraoperative variables, postoperative complications, pain severity, hospital stay, patient satisfaction, ICU admission, and 30-day mortality were analyzed. Chi-square testing and multivariable logistic regression were performed. Results: Postoperative delirium was lower with neuraxial anesthesia than general anesthesia (12.8% vs 26.4%; p=0.004), as were pulmonary complications (10.3% vs 23.6%; p=0.003), severe pain at 24 hours (12.8% vs 23.6%; p=0.001), ICU admission (11.5% vs 23.6%; p=0.008), and 30-day mortality (3.8% vs 9.7%; p=0.047). General anesthesia was independently associated with postoperative complications (adjusted OR 2.14, 95% CI 1.28–3.56; p=0.004) and 30-day mortality (adjusted OR 2.62, 95% CI 1.01–6.78; p=0.047). Conclusion: Neuraxial anesthesia was associated with more favorable postoperative outcomes than general anesthesia among elderly hip fracture patients, although anesthetic selection should remain individualized because of the observational study design
No takes yet. Share an insight, caveat, or question.
Hussain et al. (2026) conducted an observational in Hip fracture (n=300). Neuraxial anesthesia vs. General anesthesia was evaluated on 30-day mortality (adjusted OR 2.62, 95% CI 1.01-6.78, p=0.047). Neuraxial anesthesia was associated with lower 30-day mortality (3.8% vs 9.7%) compared to general anesthesia, with general anesthesia independently associated with increased mortality risk (adjusted OR 2.62) in elderly hip fracture patients.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: