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Mitochondrial carrier homolog 2 (MTCH2) acts as a negative regulator of energy metabolism in adipocytes by modulating CPT1 sensitivity to malonyl-CoA, and its ablation enhances whole-body energy expenditure independently of UCP1. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

October 3, 2025Nature Communications7 citationsOpen Access

MTCH2 modulates CPT1 activity to regulate lipid metabolism of adipocytes

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Authors

CWChunyan Wu TWTongtong Wang AGAdhideb Ghosh

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Wu et al. (2025) studied this question.

synapsesocial.com/papers/6a658ac4e118a1f920358073 https://doi.org/10.1038/s41467-025-63880-7

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October 3, 2025Nature Communications7 citationsOpen Access

MTCH2 modulates CPT1 activity to regulate lipid metabolism of adipocytes

View Full Paper

Ask AI

Bookmark

Authors

CWChunyan Wu TWTongtong Wang AGAdhideb Ghosh

Discussion

Member takes

Overview

Key Points

Key points are not available for this paper at this time.

Cite This Study

Wu et al. (2025) studied this question.

synapsesocial.com/papers/6a658ac4e118a1f920358073 https://doi.org/10.1038/s41467-025-63880-7

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