Key result
Hip fracture was associated with an increased risk of stroke during 1-year follow-up compared to matched controls (4.1% vs 2.7%; adjusted HR 1.53; 95% CI 1.17-2.01; P=0.002).
Why the study?
Does hip fracture increase the risk of stroke in the following year?
Cohort (n=8,404)
Yes
Does hip fracture increase the risk of stroke in the following year?
Hazard Ratio: 1.53 (95% CI 1.17–2.01)
Absolute Event Rate: 4.1% vs 2.7%
p-value: p=0.002
Hip fracture is associated with a significantly increased risk of stroke in the subsequent year, highlighting the need for cardiovascular risk assessment in this population.
Warrants stroke vigilance after hip fracture; observational data leaves open causality and practice change.
BACKGROUND AND PURPOSE: Stroke is a documented risk factor for hip fracture. However, no documented studies are available on the risk of stroke among patients with hip fracture. This study investigated the frequency and risk of stroke after hip fracture using a nationwide population-based study. METHODS: The study cohort included 2101 patients hospitalized with a principal diagnosis of hip fracture from 2001 to 2004. The comparison cohort consisted of 6303 randomly selected subjects matched on sex, age, and year of index healthcare use as controls. We tracked patients for a 1-year period from their index healthcare encounter to identify those who had a stroke. Stratified Cox proportional hazard regression was performed to evaluate the association of hip fracture with subsequent stroke during 1-year follow-up. RESULTS: Of a total of 8404 patients, 86 (4.1%) from the study group and 170 (2.7%) from the comparison group had strokes during the follow-up period (P<0.001). The stratified Cox proportional analysis shows that the 1-year crude hazard of stroke among patients with hip fracture was 1.55 times (95% CI, 1.19 to 2.03; P=0.001) that of the comparison group. Furthermore, after adjusting for the major cardiovascular risk factors, the increased stroke risk of patients with hip fracture persisted at about the same level as in the unadjusted analysis (hazard ratio, 1.53; 95% CI, 1.17 to 2.01; P=0.002). CONCLUSIONS: Hip fracture is associated with increased risk of stroke in the next year.
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Kang et al. (2010) conducted a cohort in Hip fracture (n=8,404). Hip fracture vs. Matched controls without hip fracture was evaluated on Stroke (HR 1.53, 95% CI 1.17 to 2.01, p=0.002). Hip fracture was associated with an increased risk of stroke during 1-year follow-up compared to matched controls (4.1% vs 2.7%; adjusted HR 1.53; 95% CI 1.17-2.01; P=0.002).
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