Key result
Elevated vasospasm index is linked to reduced cerebral blood flow and worse clinical condition.
Observational (n=24)
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Assesses vasospasm effects on cerebral blood flow and oxygen extraction in subarachnoid haemorrhage, indicating monitoring utility.
A spasm index, defined as transcranial Doppler detected flow velocity in the middle cerebral artery divided by regional cortical cerebral blood flow (CBF), was used on 24 patients with subarachnoid haemorrhage (SAH). The aim was to estimate degree and time course of vasospasm, even in cases with great day-to-day variation in CBF, and correlate to CBF and oxygen extraction. All patients showed increase in spasm indices with peak index in the second or third week. The index seemed stable in spite of day-to-day fluctuations in CBF. Severe vasospasm were associated with poor clinical condition, reduced CBF (less than 30) and high AVDO2. The same picture could be seen with minor degree of vasospasm, probably, in some cases, due to high intracranial pressure. The results suggest that the spasm index is useful in monitoring patients with subarachnoid haemorrhage, and that severe vasospasm has a negative influence on clinical condition, CBF and oxygen extraction.
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Jakobsen et al. (2009) conducted an observational in Subarachnoid haemorrhage (SAH) (n=24). Vasospasm (measured by spasm index) was evaluated on Correlation of spasm index with cerebral blood flow and oxygen extraction. Severe vasospasm, indicated by an elevated spasm index, was associated with poor clinical condition, reduced cerebral blood flow (<30), and high oxygen extraction.
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