Key result
Macrophage polarization is a dynamic, non-fixed process that allows macrophages to integrate multiple environmental signals from microbes and damaged tissues.
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Macrophage plasticity in integrating signals warrants caution against fixed phenotypes in therapy; leaves open targeted cardiovascular interventions.
Martin G. Cogan (1990) studied this question. Macrophage polarization is a dynamic, non-fixed process that allows macrophages to integrate multiple environmental signals from microbes and damaged tissues.