Detergent activity is conferred upon a cell-penetrating peptide by dipalmitoylation, and the peptide can incorporate large amounts of phospholipid into supramolecular particles with unique physicochemical properties. These nanocarriers combine the advantages of both liposomes and micelles as they offer a membrane-like environment in spite of their small size, thus preserving the biofunctionality of the vector peptide and affording efficient internalization into live cells.
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Keller et al. (2005) studied this question.
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