Cigarette Smoke Induces the Pro-inflammatory Response of Lung Macrophages via Activation of the IL-33/ST2-Dependent Pathway

Q: What does this research mean for the field?

Cigarette smoke extract-activated, IL-33/ST2-driven pro-inflammatory macrophages drive neutrophilic inflammation and Th17 skewing, linking innate and adaptive immune responses in airway inflammation. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

Yujin Kim; Yosep Mo; Ji‐Young Bang; Jihyun Kim; I J Lee; Hye Young Kim; Hye-Ryun Kang

doi:10.4110/in.2026.26.e17

January 1, 2026Immune NetworkOpen Access

Cigarette Smoke Induces the Pro-inflammatory Response of Lung Macrophages via Activation of the IL-33/ST2-Dependent Pathway

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Key Points

The study aims to explore how cigarette smoke affects lung macrophages and their inflammatory response through the IL-33/ST2 pathway.
Investigated the activation of the IL-33/ST2 pathway in lung macrophages following cigarette smoke exposure.
Assessed Th17 differentiation and neutrophilic inflammation as outcomes of the pro-inflammatory response.
Utilized cellular assays to analyze immune response dynamics.
Cigarette smoke exposure significantly activated lung macrophages via the IL-33/ST2 pathway.
Enhanced Th17 differentiation was observed, indicating a skew toward adaptive immune responses.
Pro-inflammatory macrophages contributed to increased neutrophilic inflammation.

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Implication

Shows activation of IL-33/ST2 pathway drives inflammation in lung macrophages, suggesting links in immune response.

Abstract

T cells toward Th17 differentiation. These findings suggest that CSE-activated, IL-33/ST2-driven pro-inflammatory macrophages drive neutrophilic inflammation and Th17 skewing, linking innate and adaptive immune responses in airway inflammation.

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Cite This Study

Kim et al. (2026) studied this question.

synapsesocial.com/papers/6a65919145cc8c5482c087b5 https://doi.org/10.4110/in.2026.26.e17

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Cigarette Smoke Induces the Pro-inflammatory Response of Lung Macrophages via Activation of the IL-33/ST2-Dependent Pathway

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Cigarette Smoke Induces the Pro-inflammatory Response of Lung Macrophages via Activation of the IL-33/ST2-Dependent Pathway

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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