What does this research mean for the field?

Go protein is a critical and highly abundant signaling molecule in the central nervous system that modulates cellular function by coupling cell surface receptors to effectors such as ion channels, enzymes, and small GTPases. Novelty: ClaimNovelty.SYNTHESIS. Consensus alignment: ConsensusAlignment.NEUTRAL.

January 1, 2009Neurosignals134 citationsOpen Access

Molecular Mechanisms of Go Signaling

MJMeisheng JiangUniversity of California, Los Angeles NBNeil S. BajpayeeUniversity of California, Los Angeles

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Abstract

Go is the most abundant G protein in the central nervous system, where it comprises about 1% of membrane protein in mammalian brains. It functions to couple cell surface receptors to intercellular effectors, which is a critical process for cells to receive, interpret and respond to extracellular signals. Go protein belongs to the pertussis toxin-sensitive Gi/Go subfamily of G proteins. A number of G-protein-coupled receptors transmit stimuli to intercellular effectors through Go. Go regulates several cellular effectors, including ion channels, enzymes, and even small GTPases to modulate cellular function. This review summarizes some of the advances in Go research and proposes areas to be further addressed in exploring the functional role of Go.

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