Key result
Pediatric patients with severe sepsis demonstrated abnormal left ventricular longitudinal strain (-13.0%; p=0.04) compared with healthy controls, despite normal ejection fraction.
Why the study?
Current echocardiographic metrics are limited in detecting early biventricular impairment in pediatric sepsis-induced myocardial dysfunction, which could otherwise aid hemodynamic management.
Does strain echocardiography identify early cardiac dysfunction associated with illness severity in pediatric sepsis compared to conventional echocardiographic methods?
Observational (n=107)
No
Does strain echocardiography identify early cardiac dysfunction associated with illness severity in pediatric sepsis compared to conventional echocardiographic methods?
Strain echocardiography can detect early biventricular dysfunction in pediatric sepsis that correlates with illness severity, even when conventional ejection fraction and fractional shortening remain normal.
Answers are grounded in this paper and cite their sources.
Abnormal LV strain despite normal EF was associated with severity in pediatric sepsis; hypothesis-generating and requires prospective validation before clinical adoption.
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Patel et al. (2020) conducted an observational in Pediatric sepsis (n=107). Severe sepsis vs. Healthy controls was evaluated on Left ventricular longitudinal strain (p=0.04). Pediatric patients with severe sepsis demonstrated abnormal left ventricular longitudinal strain (-13.0%; p=0.04) compared with healthy controls, despite normal ejection fraction.
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