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Adaptive CD4+ T cells are critical for the generation of effective memory CD8+ T-cell responses to SIV, and CD8+ T cells induced during CD4+ deficiency provide reduced protection against infection. Novelty: ClaimNovelty.CONFIRMATORY. Consensus alignment: ConsensusAlignment.SUPPORTS_CONSENSUS.

July 31, 2008Journal of Virology

Reduced Protection from Simian Immunodeficiency Virus SIV mac251 Infection Afforded by Memory CD8 + T Cells Induced by Vaccination during CD4 + T-Cell Deficiency

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Authors

MVMonica VaccariTulane University JMJoseph J. MattapallilUniformed Services University of the Health Sciences KSKaimei SongNational Institutes of Health

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Cite This Study

Vaccari et al. (2008) studied this question.

synapsesocial.com/papers/6a659c3166b3f59c44c4d6ea https://doi.org/10.1128/jvi.00893-08

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Reduced Protection from Simian Immunodeficiency Virus SIV mac251 Infection Afforded by Memory CD8 + T Cells Induced by Vaccination during CD4 + T-Cell Deficiency

Discussion

Member takes

Implication

Key Points

Cite This Study

Reduced Protection from Simian Immunodeficiency Virus SIV mac251 Infection Afforded by Memory CD8 + T Cells Induced by Vaccination during CD4 + T-Cell Deficiency

Discussion

Member takes

Implication

Key Points

Cite This Study

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