Key result
Huxley and Hill muscle-tendon complex models yielded similarly adequate predictions of mechanical muscle behavior during stretch-shortening cycles in rat soleus muscle.
Effect estimate: R(2)>0.97 for part 1 fitting
Huxley and Hill muscle-tendon complex models are equally valid with respect to predicting mechanical behavior during stretch-shortening cycles in rat soleus muscle.
Both Hill and Huxley MTC models predict rat soleus SSC force comparably; leaves open metabolic integration for in vivo human modeling.
The relationship between mechanical and metabolic behaviour in the widely used Hill muscle-tendon complex (MTC) model is not straightforward, whereas this is an integral part of the Huxley model. In this study, we assessed to what extent Huxley- and Hill-type MTC models yield adequate predictions of mechanical muscle behaviour during stretch-shortening cycles (SSCs). In fully anaesthetized male Wistar rats (N=3), m. soleus was dissected completely free, except for the insertion. Cuff electrodes were placed over the n. ischiadicus. The distal end of the tendon was connected to a servo motor, via a force transducer. The setup allowed for full control over muscle stimulation and length, while force was measured. Quick-release and isovelocity contractions (part 1), and SSCs (part 2) were imposed. Simulations of part 2 were made with both a Hill and a Huxley MTC model, using parameter values determined from part 1. Modifications to the classic two-state Huxley model were made to incorporate series elasticity, activation dynamics, and active and passive force-length relationships. Results were similar for all rats. Fitting of the free parameters to the data of part 1 was near perfect (R(2)>0.97). During SSCs, predicted peak force and force during relaxation deviated from the experimental data for both models. Overall, both models yielded similarly adequate predictions of the experimental data. We conclude that Huxley and Hill MTC models are equally valid with respect to mechanical behaviour.
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Lemaire et al. (2016) studied this question. Huxley MTC model vs. Hill MTC model was evaluated on Prediction of mechanical muscle behaviour during stretch-shortening cycles (R(2)>0.97 for part 1 fitting). Huxley and Hill muscle-tendon complex models yielded similarly adequate predictions of mechanical muscle behavior during stretch-shortening cycles in rat soleus muscle.
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