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July 26, 2026Brazilian Journal of MicrobiologyOpen Access

Pangenomic and genomic plasticity analyses of the genus Rickettsia

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Authors

PMPaula Cristina de MagalhãesAFAndrei Giacchetto FeliceSSSiomar Soares

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Overview

Randomized trial analyzes genetic variability and adaptability in Rickettsia species, indicating evolutionary contrasts.

Key Points

  • This research investigates the pangenomic and genomic plasticity of the Rickettsia genus to understand genetic diversity and evolutionary dynamics.
  • Analyzed 165 genomes from 31 Rickettsia species available in the REFSEQ database.
  • Utilized tools such as Orthofinder, ANIclustermap, Gegenees, and Mauve for gene classification and genomic analysis.
  • Conducted statistical correlations to assess core genome stability relative to pangenome expansion.
  • The Rickettsia genus exhibits an open pangenome (α = 0.842), indicating high genetic variability.
  • R. typhi has a nearly closed pangenome (α = 0.999), suggesting high genomic conservation.
  • R. rhipicephali demonstrates greater plasticity with an open pangenome (α = 0.876), reflecting intraspecies diversity.

Cite This Study

Magalhães et al. (2026) studied this question.

synapsesocial.com/papers/6a65a49fd3aea3239cd771a7https://doi.org/10.1007/s42770-026-02030-7
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