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July 26, 2026Exploration of Neuroprotective TherapyOpen Access

Do selective serotonin reuptake inhibitors enhance post-stroke recovery beyond mood? An updated, narrative mini-review

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Authors

GVGiulio Verrienti

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Overview

Narrative mini-review explores SSRI effects on recovery outcomes in stroke patients, suggesting limited benefits.

Key Points

  • This review examines the potential neurorestorative effects of SSRIs on recovery after stroke, beyond mood improvements.
  • Summarized current clinical evidence regarding SSRI use for motor and cognitive recovery after stroke.
  • Reviewed early small-scale studies and subsequent large multicenter randomized controlled trials.
  • Evaluated the discrepancies between mechanistic theories and observed clinical outcomes.
  • Early studies indicated some improvement in motor performance with fluoxetine, but large trials did not confirm benefits on global outcomes.
  • Large trials reported increased risks of adverse events such as fractures and seizures in stroke patients.
  • Current data do not support SSRIs as neurorestorative agents in non-depressed stroke patients.

Cite This Study

Giulio Verrienti (2026) studied this question.

synapsesocial.com/papers/6a65a501d3aea3239cd77491https://doi.org/10.37349/ent.2026.1004165
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