Pd-Catalyzed Cycloamination of Heterocyclic Iodides, Norbornenes, and Diaziridinone

Junhua Li; Zhu Tao; Ying Liu; Yian Shi

doi:10.1021/acs.orglett.6c02399

July 23, 2026Organic Letters

Pd-Catalyzed Cycloamination of Heterocyclic Iodides, Norbornenes, and Diaziridinone

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Key Points

This research aims to develop an efficient method for synthesizing pyrrole-fused bis-heterocycles using palladium-catalyzed cycloamination reactions.
Utilized palladium-catalyzed cycloamination of heterocyclic iodides and norbornenes.
Implemented cascade Heck reactions followed by C-H activation.
Investigated various pyrrole-fused bis-heterocycles synthesized.
Successfully generated a wide range of pyrrole-fused bis-heterocycles.
Achieved efficient reaction processes through cascade mechanisms.
Demonstrated the versatility of the approach with various heterocycles.

Abstract

-butyldiaziridinone is described. A wide variety of pyrrole-fused bis-heterocycles can be efficiently generated via cascade Heck/C-H activation/amination reaction processes through heterocycle-norbornene palladacycles.

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Cite This Study

Li et al. (2026) studied this question.

synapsesocial.com/papers/6a65a501d3aea3239cd77530 https://doi.org/10.1021/acs.orglett.6c02399

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Pd-Catalyzed Cycloamination of Heterocyclic Iodides, Norbornenes, and Diaziridinone

Key Points

Abstract

Discussion

Cite This Study

Pd-Catalyzed Cycloamination of Heterocyclic Iodides, Norbornenes, and Diaziridinone

Key Points

Abstract

Discussion

Cite This Study

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