Numerical model predicts electric field effects of nanoparticles during electroporation in electrochemotherapy.
Purpose This study aims to present a numerical model to predict the electric field distribution in the presence of conductive or dielectric nanoparticles close to the cell membrane during electrochemotherapy treatment. Design/methodology/approach To solve the electromagnetic problem in transient conditions, finite element analyses are performed. Specifically, the field distribution during both the rise and the constant period of the pulse is investigated. To analyze the impact of the pulse dynamics, different rise times are considered. Findings The effect of a trapezoidal voltage pulse on the electric field distribution in a region of interest close to the nanoparticle is studied, considering nanoparticles made of conductive or dielectric materials. Originality/value The effect of different nanoparticle materials is studied, as well as the effect of the pulse rise time.
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Bernardini et al. (2026) studied this question.
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