What question did this study set out to answer?

This study aims to examine the correlation between antineuronal antibodies and clinical outcomes in patients with paraneoplastic neurological syndromes.

July 26, 2026DiagnosticsOpen Access

Anti-Zic4- and Anti-NMDAR-Positive Patients and Their Correlation with Clinical Course and Image Diagnostic Findings—Case Reports

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Authors

MHMilen Veselinov HristozovMedical University Plovdiv KSKrasimir ShukerskiMedical University Plovdiv AYAntoniya YanevaMedical University Plovdiv

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Implication

Case reports investigate neuroimaging abnormalities and antibody presence in PNS patients, suggesting clinical implications.

Key Points

This study aims to examine the correlation between antineuronal antibodies and clinical outcomes in patients with paraneoplastic neurological syndromes.
Two patients with PNS were examined for antineuronal antibodies using indirect immunofluorescence assay and immunoblotting.
Computed tomography and magnetic resonance imaging scans identified focal lesions suggestive of neurological degeneration and tumors.
Long-term follow-up was emphasized for early detection of potential malignant neoplasia.
Both patients were anti-Zic4-positive; one was also anti-NMDAR-positive.
Neuroimaging revealed abnormalities indicating paraneoplastic cerebellar degeneration; no tumors found upon follow-up.
A correlation between anti-Zic4 and paraneoplastic cerebellar degeneration was observed, while anti-NMDAR was linked to autoimmune encephalitis.

Cite This Study

Hristozov et al. (2026) studied this question.

synapsesocial.com/papers/6a65a5bad3aea3239cd7776f https://doi.org/10.3390/diagnostics16152304

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Anti-Zic4- and Anti-NMDAR-Positive Patients and Their Correlation with Clinical Course and Image Diagnostic Findings—Case Reports

Discussion

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Implication

Key Points

Cite This Study

Anti-Zic4- and Anti-NMDAR-Positive Patients and Their Correlation with Clinical Course and Image Diagnostic Findings—Case Reports

Discussion

Member takes

Implication

Key Points

Cite This Study

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